Engineering Biology for a Healthier Planet

Biotechnology is enabling innovation far beyond biopharma, delivering cleaner water, purifying the air we breathe, eliminating forever chemicals from ecosystems, and providing innovative ways to sustainably produce food, materials, and energy.

Notable Breakthroughs Enabling Climate Biotech

From bioengineered crops to carbon-negative materials, biotechnology has delivered impactful innovations that address pressing challenges in climate and food systems.

Synthetic Biology

Integrating computational and experimental approaches to map, understand, and engineer complex biological systems.

CRISPR & Recombinant DNA

Precision bioengineering tools enabling faster, and more dynamic gene editing, unlocking new functions in organisms.

Metabolic Engineering

Improving and introducing novel metabolic networks in microbes to biomanufacture food, fuels, and high-value bioproducts.

DNA Synthesis & Sequencing

Revolutionizing biotech research by increasing the experimental output in bioengineering workflows.

ValleyDAO Research Focus

Key areas that we focus on for advancing climate biotechnology solutions.

From Microbes to Meals: Scalable Food Production for 10 Billion People

In a world with rapidly increasing costs, carbon emissions, and concern for where our everyday products come from, bioproduction has an answer. Scientists and bioprospectors are scouring the globe for useful microbes that have already unlocked other-worldy capabilities: textiles from trash, food with 99% less land use, a rewilding of the nature our ancestors degraded. Not only can precision fermentation deliver on these outlandish futures, but it has already provided antibiotics for the sick. Penniclin, the first antibiotic that’s saved millions if not billions of lives, was found in a natural fungus. Scientists and engineers then worked tirelessly to scale production of this miracle drug. Today the next revolution in fermentation is bringing us new detergents, new fuels, new foods, safer dyes, and natural pesticides at industrial scales. At ValleyDAO we’re investing in this future, where little workhorses create earth-friendly products for everyday use.

If interested in a deep-dive on this up-and-coming industry check out this Nature Review.

ValleyDAO Projects in This Focus Area
Cocoa ZERO: Beanless Chocolate, Lighter Footprint

Cocoa ZERO makes real chocolate taste using precision fermentation, not faraway plantations. We grow cocoa lipids locally in steel tanks, 90 percent matched to cocoa butter, then blend with sustainable beans for bars that melt like classic chocolate with a lighter footprint and a more reliable supply.

$300,000

Crowdfunded

SynbioCAD: AI Powered Strain Engineering

Biology is the new engineering, but strain design is still slow and fragmented. SynbioCAD unifies the computational toolkit, from target molecule to lab ready experiments, with AI that ranks pathways and a cell-free platform that tests and validates the most promising bioproduction routes. Bioengineering teams cut design time from months to weeks and move to build with confidence.

Currently in Incubation

Rope as Strong as Spider’s Silk, Planet Friendly Plastic, and More

Biomaterials have been used for millennia, now they’re taking the next leap. Industrial biotechnology is enabling the engineering and market-scale production of biomaterials for everyday life. Your favorite brand of detergent will soon have next generation chemicals that are not only high performing but do not require harmful chemicals made from fossil fuels. For thousands of years we’ve made clothes out of silk, cotton, and leather. Now, these expensive and industrially cultivated fibers can be made from engineered microbes, consuming less water, energy, and land in the process. Scientists are also engineering microbes to recycle plastics, produce biodegradable plastics, or even replace plastics with fungal mycelium. In the future, your local supermarket will be stocked with high performance, planet-friendly materials, made with less inputs and better quality.

Check out this Nature Review to learn more.

ValleyDAO Projects in This Focus Area
BioHalo: Forever Chemicals Disrupted by Biology

BioHalo engineers microbes for precision biohalogenation, building next-gen fluoropolymers that match PFAS performance while staying biodegradable. Their enzymatic toolkit rewires metabolic pathways to insert single fluorine atoms with atom-level control, creating safe, high-value materials.

$1,900,000

External Funding Raised

Crop Innovation for Tough Climates and Higher Productivity

Plant genetics has come a long way since Gregor Mendel’s peas. Now scientists and engineers create plant coatings that protect and invigorate early plant growth, also allowing early planting and less fertilizer. New engineered microbes help plants easily access nitrogen in the soil, reducing farmers’ costs and reducing algae blooms from soil runoff. Not only can we engineer biology to assist the plants, but we can also engineer the plants themselves, allowing for efficient land usage, improved survival, and increased yields. Through genetic engineering we can feed the future, help the planet, and lower farmer costs. Scientists can now address some of the biggest challenges in food scarcity by engineering agricultural operations for unique environments. Check out this article to see how biotechnology is meeting Africa’s need for resilient agriculture.

ValleyDAO Projects in This Focus Area

We've yet to fund a project in this focus area. Are you a researcher or entrepreneur working on this? Click Learn More to find out how we can support your work.

Capture and Create: Biology That Turns Carbon into Useful Products

Carbon capture is not the headline. Utilization by living factories is. Bioengineered microbes, algae, and plants can fix CO2 and route it into fuels, polymers, and everyday ingredients.

Think cyanobacteria that use sunlight to turn CO2 into chemicals, acetogenic bacteria that eat CO2 plus hydrogen to make ethanol and jet fuel precursors, and engineered yeasts that convert CO2-derived feedstocks into oils and surfactants.

Picture neighborhood biorefineries that grow these industrial trees in tanks, harvesting rubber precursors, plastics, and gasoline substitutes without drilling. The organisms pull carbon from air, flue gas, and fermentation off gases, then upgrade it into valuable products. This is a closed carbon loop built from biology, not oil wells.

Check out this article for a deeper dive.

ValleyDAO Projects in This Focus Area

We've yet to fund a project in this focus area. Are you a researcher or entrepreneur working on this? Click Learn More to find out how we can support your work.

Waste In, Value Out with Biology

Instead of digging new mines, drilling new oil wells, expanding landfills, or shipping virgin materials across oceans, we harvest what we already discard and turn it into fresh feedstocks for industry. Biorecovery closes material loops, lowers extraction risk, and builds local supply chains that scale with electricity and bioprocessing capacity rather than new pits.

In e-waste recycling, tailored microbes and bio-based ligands can solubilize and selectively recover metals like copper, gold, and rare earths from shredded electronics, supplying cleaner inputs for chips and batteries.

In wastewater and flue gas, algae and microbial consortia remove nitrogen, phosphorus, and CO2, then convert them into fertilizers, bio-oils, and platform chemicals.

In plastics and textiles, designer enzymes depolymerize PET and polyurethane into monomers that microbes rebuild into new polymers and other high-value materials.

Check out this article for a deeper dive.

ValleyDAO Projects in This Focus Area
Forge: Metal Sovereignty through Biomining

Access to critical minerals now shapes national strength. Export controls, trade frictions, and rising demand for artificial intelligence, electric vehicles, and defense systems strain global supplies. CSIRO’s integrated biomining technology turns electronic waste into a domestic resource. The bioprocess has the potential to decrease energy and chemical use in contrast to traditional recycling methods.

$200,000

Crowdfunded

Glowing Plants and Living Materials

Tomorrow's textiles, detergents, and everyday materials will increasingly come from biology. Novel enzymes and engineered microbes replace petroleum chemistry with lower-impact, fermentation-made routes. Engineered textiles, algae-based skin care, and fermentation-derived antioxidants already show biology can deliver performance and sustainability.

Living materials bring biology into the home: bioluminescent plants and algae offer low-energy light and learning opportunities, while engineered plants can reduce surface and air pathogen.

With responsible design, testing, and oversight, consumer biotechnology can make homes healthier and change our relationship with nature.

Learn more here.

ValleyDAO Projects in This Focus Area

We've yet to fund a project in this focus area. Are you a researcher or entrepreneur working on this? Click Learn More to find out how we can support your work.

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